AHA-BUCH

Selective cell control for biomedical applications

Impact of laser-fabricated 3D scaffolds and surface topographies
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ISBN-13:
9783838118147
Einband:
Paperback
Seiten:
140
Autor:
Sabrina Schlie
Gewicht:
225 g
Format:
220x150x8 mm
Sprache:
Englisch
Beschreibung:

In biomedical research biomaterial-cell interaction are of huge importance. One issue refers to the application of three-dimensional (3D) scaffolds to guide tissue formation and reconstruction. To improve implant adaptation a selective cell control is required. For this purpose, material functionalization methods such as providing surface topographies are under development. In this dissertation defined 3D scaffolds and topographies in micro- and nanometer scale were fabricated via laser-based nanoengineering at the Laser Zentrum in Hannover e.V., Germany. Indeed, the laser-fabricated constructs enabled a selective control of cellular behavior. With focus on adhesion ligands from the extracellular matrix, cell specific differences in adhesion mechanism could further be demonstrated. These findings not only help to explain the observed results, but also facilitate material search and functionalization for future biomedical applications.

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