AHA-BUCH

Genetic algorithm for haplotyping and block partitioning

A parsimony-based approach
 Paperback
Print on Demand | Lieferzeit:3-5 Tage I

59,00 €*

Alle Preise inkl. MwSt. | zzgl. Versand
ISBN-13:
9783639237849
Einband:
Paperback
Seiten:
132
Autor:
Nadezhda Sazonova
Gewicht:
213 g
Format:
220x150x8 mm
Sprache:
Englisch
Beschreibung:

A new algorithm for performing simultaneous haplotype resolution and block partitioning is proposed. The algorithm is based on genetic algorithm approach and the parsimonious principle. The multiloculs LD measure (Normalized Entropy Difference) is used as a block identification criterion. The proposed algorithm incorporates missing data is a part of the model and allows blocks of arbitrary length. In addition, the algorithm provides scores for the block boundaries which represent measures of strength of the boundaries at specific positions. The results show that the proposed genetic algorithm provides the accuracy of haplotype decomposition within the range of the same indicators shown by the other algorithms. The proposed algorithm is also used in a new population clustering algorithm, which extracts from the given genotype sample two clusters with substantially different block structures and finds haplotype resolution and block partitioning for each cluster.

Kunden Rezensionen

Zu diesem Artikel ist noch keine Rezension vorhanden.
Helfen sie anderen Besuchern und verfassen Sie selbst eine Rezension.