Providing more than just a comprehensive history, critical vocabulary, insightful compilation of motivations, and clear explanation of the state-of-the-art of modern clinical trial simulation, this book supplies a rigorous framework for employing simulation as an experiment, according to a predefined simulation plan, that reflects good simulation p

Introduction to Simulation for Design of Clinical Trials. Models for Simulation. Computation in Simulation. Analyses of the Simulations. Perspectives on Clinical Trial Simulation. Applications. Index.