AHA-BUCH

1,3-Pyrimidine Derivatives

Synthesis and Antimicrobial Activity
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ISBN-13:
9783848488353
Einband:
Paperback
Seiten:
116
Autor:
Anoop Kumar Pathak
Gewicht:
189 g
Format:
220x150x7 mm
Sprache:
Englisch
Beschreibung:

99
There has been growing menace of antibiotic resistance in recent past owing to a number of reasons such as self medication and non-compliance on parts of patients with regard to complete dosage regimen. Medicinal chemists are hard pressed to bring about new molecules to cater to this need. 1,3-pyrimidine derivatives have been explored by a number of scientists worldwide and such these derivatives have emerged potential lead molecules for development of newer antimicrobial moieties. The present work reports the syntheses and evaluation of some 2-(6 -fluorobenzothiazol-2 -ylamino)-4,6-(disubstituted thiouriedo) -1,3-pyrimidine derivatives. Some of the synthesized derivatives showed excellent activity against Gram +ve bacteria Staphyllococcus aureus, Bacillus subtilis, and Gram -ve bacteria Escherichia coli and Pseudomonas aeruginosa. The contents of this book must make an excellent read for those interested in antibiotic research and allied interests.