AHA-BUCH

Interleukin-17 is a key cytokine in first-line defence of the skin

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ISBN-13:
9783838117560
Einband:
Paperback
Seiten:
92
Autor:
Kilian Eyerich
Gewicht:
153 g
Format:
220x150x6 mm
Sprache:
Englisch
Beschreibung:

Communication between cells as a prerequisite for life of multicellular organisms is achieved mostly by solvent mediators like hormons, neurotransmitters, cytokines and chemokines. Increasing evidence suggests that a class of cytokines exists that signals from immune cells specifically towards epithelial cells. The most prominent member of these "tissue-signaling cytokines" is Interleukin-17 (IL-17). This book illustrates IL-17 is essential to protect the human organism at its skin surface against invading microorganisms. Cellular sources of IL-17 and trigger factors of IL-17 secretion in the skin are defined. Finally, this book identifies two human diseases associated with chronic infections of the skin that are at least partially caused by a disturbed IL-17 pathway - the orphan syndrome "chronic mucocutaneous candidiasis" and the very common inflammatory skin disease "atopic dermatitis/ eczema".

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