AHA-BUCH

Effects of Fluoroquinolones on the Helicase Activity of HCV

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ISBN-13:
9783659936005
Einband:
Paperback
Seiten:
160
Autor:
Irfan Khan
Gewicht:
255 g
Format:
220x150x10 mm
Sprache:
Englisch
Beschreibung:

HCV has infected 170 million individuals worldwide. Effective therapy against HCV is still lacking and there is a need to develop potent drugs against the virus. In the present study, we have employed two culture models to test the activity of fluoroquinolone drugs against HCV: a subgenomic replicon that is able to replicate independently in the cell line Huh-8 and the Huh-7 cell culture model that employs cells transfected with synthetic HCV RNA to produce the infectious HCV particles. Fluoroquinolones have also been shown to have inhibitory activity against certain viruses, possibly by targeting the viral helicase.