AHA-BUCH

Development of Self Microemulsifying Drug Delivery System

Design and Development of Self Microemulsifying Drug Delivery System of Clopidogrel Bisulphate
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ISBN-13:
9783659404795
Einband:
Paperback
Erscheinungsdatum:
04.06.2013
Seiten:
108
Autor:
Priyank B. Patel
Gewicht:
177 g
Format:
220x150x6 mm
Sprache:
Englisch
Beschreibung:

99
Nearly 40% of new drug candidates exhibit low solubility in water, which leads to poor oral bioavailability, high intra- and inter-subject variability and lack of dose proportionality. Modification of the physicochemical properties, such as salt formation and particle size reduction of the compound may be one approach to improve the dissolution rate. . In recent years, much attention has focused on lipid based formulations to improve the oral bioavailability of poorly water soluble drug compounds. In fact, the most popular approach is the incorporation of the drug compound into inert lipid vehicles such as oils, surfactant dispersions, self-emulsifying formulations, emulsions and liposomes with particular emphasis on self microemulsifying drug delivery systems (SMEDDS).