AHA-BUCH

Phosphoinositide 3-kinase in Health and Disease
-29 %
Der Artikel wird am Ende des Bestellprozesses zum Download zur Verfügung gestellt.

Phosphoinositide 3-kinase in Health and Disease

Volume 2
 eBook
Sofort lieferbar | 1027 Stück | Lieferzeit:3-5 Tage I

Unser bisheriger Preis:ORGPRICE: 301,95 €

Jetzt 214,19 €*

ISBN-13:
9783642148163
Einband:
eBook
Seiten:
306
Autor:
Christian Rommel
Serie:
347, Current Topics in Microbiology and Immunology
eBook Typ:
PDF
eBook Format:
PDF
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:

PI3K (phosphoinositide 3-kinase) has been catapulted to the forefront of drug development in cancer, immunity and thrombosis. This book details key discoveries in the area, their impact and future directions.


PI3K - From the bench to the clinic and back.- Oncogenetic mutations of PIK3CA in human cancers.- Structural effects of oncogenic PI3Kalpha mutations.- Comparing the roles of the p110¿ and p110¿ isoforms of PI3K in signaling and cancer.- Phophatidylinositol 3-kinase (PI3K): the oncoprotein.- AKT Signaling in Physiology and Disease.- Faithfull modeling of PTEN loss driven diseases in the mouse.- PI3K as a target for therapy in haematological malignancies.- Clinical Development of Phosphatidylinositol-3 Kinase Pathway Inhibitors.- From the bench to the bed side: PI3K pathway inhibitors in clinical development.- New Inhibitors of the PI3K-Akt-mTOR Pathway: Insights into mTOR Signaling From a New Generation of Tor Kinase Domain Inhibitors (TORKinibs).- Small molecule inhibitors of the PI3-kinase family.- Targeting the RTK-PI3K-mTOR axis in malignant glioma: overcoming resistance.- Subject index

Contents of sister volume 1:
PI3K Book Introduction.- PDK1: The major transducer of PI 3-kinase actions.- Protein Kinase B (PKB/Akt), a key mediator of the PI3K signaling pathway.- Regulatory subunity of class IA PI3K.- The Regulation of Class IA PI 3-kinases by Inter-Subunit Interactions.- Phosphoinositide signalling pathways in metabolic regulation.- Role of RAS in the regulation of PI 3-kinase.- More than just kinases: the scaffolding function of PI3K.- PI3K signalling in neutrophils.- PI 3-kinase p110¿ Regulation of Platelet Integrin ¿IIb¿3.- PI3Ks in lymphocyte signaling and development.- the neurodevelopmental implication of PI3K signaling.- PI3kinase regulation of skeletal muscle hypertrophy and atrophy.- Taking PI3Kdelta and PI3Kgamma one step ahead - Dual active PI3Kdelta/gamma inhibotrs for the treatment of immune -mediated inflammatory diseases.- Subject index
PI3K has become a very intense area of research, with over 2000 publications on PI3K in PubMed for 2009 alone. The expectations for a therapeutic impact of intervention with PI3K activity are high, and progress in the clinical arena is being monitored by many. However, targeted therapies almost invariably encounter roadblocks, often exposing unresolved questions in the basic understanding of the target