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Coronavirus Replication and Reverse Genetics
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Coronavirus Replication and Reverse Genetics

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ISBN-13:
9783540267652
Einband:
Ebook
Erscheinungsdatum:
05.10.2004
Seiten:
257
Serie:
287, Current Topics in Microbiology and Immunology
eBook Typ:
PDF
eBook Format:
PDF
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:

"Until the late 1960s, the coronaviruses were not recognized as pathogens responsible for human diseases (common cold). However, in 2003 human coronaviruses (HCoVs) came to worldwide attention with the emergence of the Severe and Acute Respiratory Syndrome (SARS), produced by a coronavirus (SARS-CoV) that infected more than 8000 people, killing about ten percent of them in 32 countries. The increase in research on coronaviruses soon led to the discovery of another human coronavirus (HCoV-NL63) which is prevalent in 7% of hospital patients and has been associated with bronchiolitis and, possibly, conjunctivitis. TOC:Coronavirus genome structure and replication.- Coronavirus transcription: a perspective.- The coronavirus replicase.- Viral and cellular proteins involved in coronavirus replication.- Coronavirus reverse genetics by targeted RNA recombination.- Coronavirus reverse genetics and development of vectors for gene expression.- Reverse genetics of coronaviruses using vaccinia virus vectors.- Development of mouse hepatitis virus and SARS-CoV infectious cDNA constructs.- Subject index."
Coronavirus genome structure and replication.- Coronavirus transcription: a perspective.- The coronavirus replicase.- Viral and cellular proteins involved in coronavirus replication.- Coronavirus reverse genetics by targeted RNA recombination.- Coronavirus reverse genetics and development of vectors for gene expression.- Reverse genetics of coronaviruses using vaccinia virus vectors .- Development of mouse hepatitis virus and SARS-CoV infectious cDNA constructs.- Subject index
The Coronaviridae family is included in the Nidovirales order together with the Arteriviridae and Roniviridae. Possibly the first recorded coro- virus-related disease was feline infectious peritonitis in 1912. However, - til the late 1960s the coronaviruses were not recognized as pathogens - sponsible for human diseases (common cold), and it was in 2003 when - man coronaviruses (HCoVs) received worldwide attention with the em- gence of the severe and acute respiratory syndrome (SARS), produced by a coronavirus (SARS-CoV), that has infected more than 8,000 people in 32 countries, killing about 10%. The increase in research on coronaviruses soon led to the discovery of another human coronavirus (HCoV-NL63), which is prevalent in 7% of hospital patients and has been associated with bronchiolitis and, possibly, conjunctivitis. Coronaviruses have been identified in mice, rats, chickens, turkeys, pigs, dogs, cats, rabbits, horses, cows, and humans. Coronaviruses are - sociated mainly with respiratory, enteric, hepatic, and central nervous s- tem diseases. In humans and fowl, coronaviruses primarily cause upper respiratory tract infections, while porcine and bovine coronaviruses est- lish enteric infections that result in severe economic losses. HCoVs are - sponsible for 10%20% of common colds, and have been implicated in gastroenteritis, high and low respiratory tract infections, and rare cases of encephalitis. HCoVs have also been associated with infant necrotizing - terocolitis and are tentative candidates for multiple sclerosis.

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