Acid sphingomyelinase deficiency enhances myelin repair
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ISBN-13:
9783330344778
Veröffentl:
2017
Einband:
Paperback
Erscheinungsdatum:
12.07.2017
Seiten:
64
Autor:
Marwan Chami
Gewicht:
113 g
Format:
220x150x4 mm
Sprache:
Englisch
Beschreibung:
In this study, we investigated the role of acid sphingomyelinase in demyelination and myelin repair by inducing acute and chronic demyelination with 5- or 12-week cuprizone treatment, followed by a 2-week cuprizone withdrawal phase to allow myelin repair.Our findings suggest that acid sphingomyelinase plays a significant role in myelin repair, and its inhibition by amitriptyline may constitute a novel therapeutic approach for multiple patients.