Pharmaceutical Powder and Particles

This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. Pharmaceutical Powder and Particles is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist.The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution; particle interaction; manufacturing processes; quality by design;and a general discussion of the industry.

This first monograph in the new AAPS book series concisely reviews important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance. Drs. Hickey and Giovagnoli have written an essential primer for any scientists involved in powder or particle research and manufacturing. It is appropriate for those just entering the field or as a rapid reference for the experienced pharmaceutical scientist.  The authors have both academic and industrial experience and the coverage includes solid state chemistry; crystallization; physical processes; particle size and distribution;particle interaction;manufacturing processes;quality by design;and a general discussion of the industry. Pharmaceutical Powder and Particles is intended to concisely review important aspects of powder and particle systems and the critical quality attributes that should be used as a guide to future developments intended to maximize the control of product quality and performance.

Introduction.- Importance of Finely Divided Solids in Pharmaceutical Dosage Forms.- Solid State Chemistry.- Crystallization.- Physical Properties.- Particle Size and Size Distribution.- Particle Size Characterization.- Fundamental of Particle Interactions.- Powder and Particle Dependent Traditional Manufacturing Processes (unit operations).- Powder and Particle Dependent Biopharmaceutical Processes.- Recent and Evolving Manufacturing Processes.- Principles of Quality by Design.- General Discussion.