Membrane Organization and Dynamics

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Amitabha Chattopadhyay
708 g
244x159x25 mm
20, Springer Series in Biophysics

Table of Contents 1 Biomembrane Organization and Dynamics: What is So Unique ? Amitabha Chattopadhyay Centre for Cellular and Molecular Biology, Hyderabad, India E-mail: amit@ccmb.res.in
2 G-protein Coupled Receptors Signaling: Membrane Diffusion and Organization matter Laurence Salomé Institute of Pharmacology and Structural Biology, CNRS, France E-mail: laurence.salome@ipbs.fr
3 Nanoparticle Probes of Single Molecule Rotation (or Motion) on Cell Surfaces George Barisas Colorado State University Fort Collins, CO, U.S.A. E-mail:george.barisas@colostate.edu
4 Organization of Membrane Proteins and Peptides using Multidimensional Microscopy Andrew Clayton Swinburne University of Technology Centre for Micro-Photonics Victoria, Australia E-mail: aclayton@swin.edu.au
5 Probing Membrane Domain Heterogeneity with k-space Image Correlation Spectroscopy Paul Wiseman Department of Chemistry McGill University Montreal, Quebec, Canada E-mail: paul.wiseman@mcgill.ca
6 Role of Membrane Domains for GPCR Functions Evgeni Ponimaskin Cellular Neurophysiology Hannover Medical School Hannover, Germany E-mail: Ponimaskin.Evgeni@mh-hannover.de
7 Investigating the Dynamics and Organization of Membrane Proteins and Lipids using Imaging Fluorescence Correlation Spectroscopy (Imaging FCS) Thorsten Wohland NUS Centre for Bio-Imaging Sciences, National University of Singapore, Singapore E-mail: twohland@nus.edu.sg
8 Combining MD Simulation and NMR Spectroscopy to Investigate the Structure and Dynamics of Membrane Constituents and Membrane Associated Proteins
9 Quantifying Membrane Protein Oligomerization by Single Molecule Methods Gerhard J. Schuetz Institute of Applied Physics Vienna University of Technology Wien, Austria E-mail: schuetz@iap.tuwien.ac.at
10 Interaction of Amphiphilic Molecules with Lipid Bilayers: Kinetics of Insertion, Desorption and Translocation Luís M. S. Loura Centro de Química de Coimbra University of Coimbra, Coimbra, Portugal E-mail: lloura@ff.uc.pt
11 Organization and Dynamics of Archaeal Tetraether Lipid Membranes Parkson Lee-Gau Chong Department of Medical Genetics & Molecular Biochemistry Temple University School of Medicine Philadelphia, Pennsylvania, U.S.A. E-mail: pchong02@temple.edu
12 Dynamics of Ion Channels in Membranes M. K. Mathew Laboratory of Membrane Biophysics National Centre for Biological Sciences, TIFR Bangalore, India E-mail: mathew@ncbs.res.in 13 Nanoscale Dynamics of Neurotransmitter Receptors and Lipid Platforms Francisco J. Barrantes Laboratory of Molecular Neurobiology Institute of Biomedical Research (BIOMED) Pontifical Catholic University of Argentina Ciudad Autónoma de Buenos Aires Argentina E-mail: rtfjb1@yahoo.com ; rtfjb1@criba.edu.ar
14 Role of Omega-3 Fatty Acids in Membrane Cholesterol Domain Formation under Disease Conditions R. Preston Mason Department of Medicine Brigham and Women's Hospital Harvard Medical School Boston, MA, U.S.A. E-mail: rpmason@elucidaresearch.com
15 Computer Simulation of Membrane Proteins
Carmen Domene, Department Chemistry, King's College, London, UK
E-mail: carmen.domene@kcl.ac.uk
16 GPCR Organization and Oligomerization: Role of Membrane Lipids Amitabha Chattopadhyay (Co-author: Durba Sengupta) Centre for Cellular and Molecular Biology, Hyderabad, India E-mail: amit@ccmb.res.in
This volume brings together information on membrane organization and dynamics from a variety of spectroscopic, microscopic and simulation approaches, spanning a broad range of time scales. The implication of such dynamic information on membrane function in health and disease is a topic of contemporary interest. The chapters cover various aspects of membrane lipid and protein dynamics, explored using a battery of experimental and theoretical approaches. The synthesis of information and knowledge gained by utilizing multiple approaches will provide the reader with a comprehensive understanding of the underlying membrane dynamics and function, which will help to develop robust dynamic models for the understanding of membrane function in healthy and diseased states.
In the last few years, crystal structures of an impressive number of membrane proteins have been reported, thanks to tremendous advances in membrane protein crystallization techniques. Some of these recently solved structures belong to the G protein-coupled receptor (GPCR) family, which are particularly difficult to crystallize due to their intrinsic flexibility. Nonetheless, these static structures do not provide the necessary information to understand the function of membrane proteins in the complex membrane milieu. This volume will address the dynamic nature of membrane proteins within the membrane and will provide the reader with an up-to date overview of the theory and practical approaches that can be used.

This volume will be invaluable to researchers working in a wide range of scientific areas, from biochemistry and molecular biology to biophysics and protein science. Students of these fields will also find this volume very useful. This book will also be of great use to those who are interested in the dynamic nature of biological processes.