Investigative Electrocardiography in Epidemiological Studies and Clini

Electrocardiology is a relatively new modality in clinical trials, but electrocardiograms (ECGs) have already become established as a valuable research tool for investigation of morbidity and mortality risk associated with various clinical and subclinical conditions. ECGs have also become a crucial tool when investigating adverse cardiac events associated with administration of new drugs.

"There is a lack of treatises dealing with investigative electrocardiographic research. Investigative Electrocardiography in Epidemiological Studies and Clinical Trials provides background information on procedures, epidemiological aspects, problem areas, mortality and morbidity risk. These topics are of particular interest for investigators in ECG research and clinical trials. This monograph is specialized beyond the scope of ordinary clinical textbooks of electrocardiography that have traditionally flooded the market. TOC:Cardiac Excitation and Repolarization.- Electrocardiographic Lead Systems.- Normal and Arrhythmogenic Ionic Channel Mechanism.- Heart Rate and Heart Rate Variability.- Methodological Considerations in Heart Rate Variability Analysis.- Supraventricular Dysrhythmias.- Ectopic Ventricular Activity.- Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs.- Left Ventricular Hypertrophy.- Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage.- Prolonged Ventricular Excitation.- Old Myocardial Infarction.- Attributable Risk.- Primary Repolarization Abnormalities.- Suggested Procedure for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements.- QT Prolongation and QT Dispersion: A Critical Evaluation.- Part 2:Normal ECG Standards for Adults by Gender, Age, and Ethnicity.- ECG Intervals.- ECG Wave Amplitudes.- ECG Vector Components and Spatial Magnitudes at Normalized Time Scale.- ECG Amplitudes at Normalized Time Scale.- Repolarization Waveform Vectors."

Investigative Electrocardiography in Epidemiological Studies and Clinical Trials.- Cardiac Excitation and Repolarization.- Electrocardiographic Lead Systems.- Normal and Arrhythmogenic Ionic Channel Mechanism.- Heart Rate and Heart Rate Variability.- Methodological Considerations in Heart Rate Variability Analysis.- Supraventricular Dysrhythmias.- Ectopic Ventricular Activity.- Record Length, Spontaneous Variability and Suppression of Ectopic Ventricular Complex Activity by Drugs.- Left Ventricular Hypertrophy.- Normal Standards for Cornell Voltage, Cornell Product and Sokolow-Lyon Voltage.- Prolonged Ventricular Excitation.- Old Myocardial Infarction.- Attributable Risk.- Primary Repolarization Abnormalities.- Procedures for Determination of the Spatial QRS/T Angle from Conventional ECG Measurements.- QT Prolongation and QT Dispersion - a Critical Evaluation.- Normal ECG Standards for Adults by Gender, Age, and Ethnicity.- ECG Intervals: Tables.- ECG Wave Amplitudes*: Tables.- ECG Vector Components and Spatial Magnitudes at Normalized Time Scale: Tables.- ECG Amplitudes at 10ms Intervals: Tables.- Repolarization Waveform Vectors: Tables.