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The Serotonin Receptors
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The Serotonin Receptors

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ISBN-13:
9781597450805
Einband:
Ebook
Seiten:
640
Serie:
The Receptors
eBook Typ:
PDF
eBook Format:
PDF
Kopierschutz:
1 - PDF Watermark
Sprache:
Englisch
Beschreibung:

"A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction."
Molecular Biology and Genomic Organization of G Protein-Coupled Serotonin Receptors

Wesley K. Kroeze and Bryan L. Roth



Structure and Function Reveal Insights in the Pharmacology of 5-HT Receptor Subtypes

Richard B. Westkaemper and Bryan L. Roth



Polymorphic and Posttranscriptional Modifications of 5-HT Receptor Structure: Functional and Pathological Implications,

Marilyn A. Davies, Chiao-ying Chang, and Bryan L. Roth



Strategies for the Development of Selective Serotonergic Agents

Richard A. Glennon



5-HT Receptor Signal Transduction Pathways

John R. Raymond, Justin H. Turner, Andrew K. Gelasco, Henry B. Ayiku, Sonya D. Coaxum, John M. Arthur, and Maria N. Garnovskaya



Agonist-Directed Trafficking of 5-HT Receptor-Mediated Signal Transduction

Kelly A. Berg and William P. Clarke



Identification of 5-HT2 and 5-HT4 Receptor-Interacting Proteins: A Proteomic Approach

Joël Bockaert, Carine Bécamel, Lara Joubert, Sophie Gavarini, Aline Dumuis, and Philippe Marin



5-HT Receptor-Associated Proteins (FRAPs): Relevance for Targeting, Trafficking, and Signal Transduction

Zongqi Xia, Douglas J. Sheffler, and Bryan L. Roth



Cellular and Subcellular Localization of Serotonin Receptors in the Central Nervous System

Laurent Descarries, Virginia Cornea-Hébert, and Mustapha Riad



Chemical Neuroanatomy of 5-HT Receptor Subtypes in the Mammalian Brain

Guadalupe Mengod, M. Teresa Vilaró, Roser Cortés, Juan F. López-Giménez, Andreu Raurich, and José M. Palacios



Modulation of the Neuronal Activity and Neurotransmitter Release by 5-HT1A and 5-HT1B/1D Receptors

Pau Celada, Albert Adell, and Francesc Artigas



Electrophysiology of 5-HT2A Receptors and Relevance for Hallucinogen and Atypical Antipsychotic Drug Actions

Evelyn K. Lambe and George K. Aghajanian



The Emergence of 5-HT2B Receptors as Targets to Avoid in Designing and Refining Pharmaceuticals

Vincent Setola and Bryan L. Roth



The 5-HT3 Receptor

Andrew J. Thompson, Li Zhang, and Sarah C. R. Lummis



5-HT3 and 5-HT4 Receptors as Targets for Drug Discovery for Dementia

Frank Lezoualc'h and Magali Berthouze



Electrophysiological Properties of Gas-Coupled 5-HT Receptors (5-HT4, 5-HT6, 5-HT7)

Rodrigo Andrade



5-HT6 Receptors as Targets for the Treatment of Cognitive Deficits in Schizophrenia

Rudy Schreiber, Andrew Sleight, and Marie Woolley



5-HT7 Receptors as Favorable Pharmacological Targets for Drug Discovery

Peter B. Hedlund and J. Gregor Sutcliffe



Serotonin System Gene Knockouts: A Story of Mice With Implications for Man

Miles Berger and Laurence H. Tecott



Effects of Serotonin-Related Gene Deletion on Measures of Anxiety, Depression, and Neurotransmission

Anita J. Bechtholt and Irwin Lucki



Index
A comprehensive, state-of-the-art review of our current understanding of the molecular and structural biology of 5-HT receptors and their potential use for drug discovery. The authors describe the anatomical, cellular, and subcellular distribution of 5-HT receptors and demonstrate a powerful approach to elucidating their physiological role using knockout mice in which the 5-HT receptors were deleted. They also review our understanding of the physiological role(s) of 5-HT receptors based mainly on studies performed in genetically engineered mice. Highlights include discussions of the behavioral phenotypes of 5-HT receptor knockout animals, the molecular biology and pharmacology of 5-HT receptors, and insights into the complexity of 5-HT receptor signal transduction.