Pharmacogenomics in Drug Discovery and Development

Covering topics from individual molecules to systemic diseases, from basic concepts to advanced technologies, Pharmacogenomics in Drug Discovery and Development , Second Edition provides a practical, state-of-the-art and integrative view of the application of pharmacogenomics in drug discovery and development. A wide range of theoretical and experimental approaches are introduced to meet the problem-solving objectives for understanding the complexity in health and diseases, from laboratory tests to computational analysis. The development of pharmacogenomics represents the evolution of biomedicine from treating the disease itself to treating the malfunction of an individual person, the "root" of diseases. With the change of focus from disease-centered to human-centric medicine, pharmacogenomics brings hope for the transformation from simple disease treatment to accurate prediction and effective prevention. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls.

From Pharmacogenomics and Systems Biology to Personalized Care: A Framework of Systems and Dynamical Medicine.- Translational Bioinformatics Approaches for Systems and Dynamical Medicine.- Whole Blood Transcriptomic Analysis to Identify Clinical Biomarkers of Drug Response.- Diagnostic Procedures for Paraffin Embedded Tissues Analysis in Pharmacogenomic Studies.- Approach to Clinical and Genetic Characterization of Statin-Induced Myopathy.- Pharmacogenetics of Membrane Transporters: A Review of Current Approaches.- G Protein-Coupled Receptor Accessory Proteins and Signaling: Pharmacogenomic Insights.- G Protein-Coupled Receptor Mutations and Human Genetic Disease.- Pharmacogenetics of the G Protein-Coupled Receptors.- Pharmacogenomics of Heart Failure.- Pharmacogenomics in the Development and Characterization of Atheroprotective Drugs.- Management of Side-Effects in the Personalized Medicine Era: Chemotherapy Induced Peripheral Neuropathy.- Pharmacogenomics of Alzheimer's Disease: Novel Therapeutic Strategies for Drug Development.- Pharmacogenetics of Antipsychotic Treatment in Schizophrenia.- Pharmacogenetics of Addiction Therapy.- Pharmacogenetics in Rheumatoid Arthritis.- The Pharmacogenomics of Osteoporotic Fractures.- Pharmacogenomics and Pharmacoepigenomics in Pediatric Medicine.- Pharmacogenomics in Children.