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Cerebral Angiogenesis
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Cerebral Angiogenesis

Methods and Protocols
 Book
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ISBN-13:
9781493903191
Einband:
Book
Erscheinungsdatum:
28.02.2014
Seiten:
442506
Autor:
Richard Milner
Gewicht:
964 g
Format:
261x185x25 mm
Serie:
1135, Methods in Molecular Biology
Sprache:
Englisch
Beschreibung:

Includes cutting-edge methods and key techniques to characterize cerebral angiogenesis
'Part I: Overview of Cerebral Angiogenesis

1. Cerebral Angiogenesis During Development: Who's Conducting the Orchestra?

Ina M. Wittko-Schneider, Fabian T. Schneider, and Karl H. Plate

2. Cerebral Angiogenesis: A Realistic Therapy for Ischemic Disease?

David A. Greenberg

3. Vascular Normalization in Cerebral Angiogenesis: Friend or Foe?

Jisook Lee, Andrew Baird, and Brian P. Eliceiri

4. Pericytes and Adaptive Angioplasticity: The Role of Tumor Necrosis Factor Weak Inducer of Apoptosis (TWEAK)

Paula Dore-Duffy

Part II: Animal Models of Cerebral Angiogenesis

5. Analysis of Angiogenesis in the Developing Mouse Central Nervous System

Nicole Ziegler, Karl H. Plate, and Stefan Liebner

6. Hypoxia-Induced Angiogenesis and Capillary Density Determination

Constantinos P. Tsipis, Xiaoyan Sun, Kui Xu, and Joseph C. LaManna

7. The Middle Cerebral Artery Occlusion Model of Transient Focal Cerebral Ischemia

Fudong Liu and Louise D. McCullough

8. A Mouse Model of Chronic Cerebral Hypoperfusion Characterizing Features of Vascular Cognitive Impairment

Masafumi Ihara, Akihiko Taguchi, Takakuni Maki, Kazuo Washida, and Hidekazu Tomimoto

9. A Mouse Model of Permanent Focal Ischemia: Distal Middle Cerebral Artery Occlusion

Kristian P. Doyle and Marion S. Buckwalter

10. A Method of Inducing Global Cerebral Ischemia

Gina Hadley, Michalis Papadakis, and Alastair M. Buchan

11. Induction of Cerebral Arteriogenesis in Mice

André Duelsner, Nora Gatzke, Anja Bondke Persson, and Ivo R. Buschmann

12. Vessel Painting Technique for Visualizing the Cerebral Vascular Architecture of the Mouse

Shea Hughes, Olkesankr Dashkin, and Richard Anthony DeFazio

13. Examining Cerebral Angiogenesis in Response to Physical Exercise

Kiersten L. Berggren, Jacob J.M. Kay, and Rodney A. Swain

Part III: Methods of Examining Cerebral Angiogenesis

14. Histological Assessment of Angiogenesis in the Hypoxic Central Nervous System

Moises Freitas-Andrade, Jacqueline Slinn, Claudie Charlebois, and Maria J. Moreno

15. Examining Vascular Remodeling in the Hypoxic Central Nervous System

Amin Boroujerdi, Jennifer V. Welser-Alves, and Richard Milner

16. Analysis of Cerebral Angiogenesis in Human Glioblastomas

Michel Mittelbronn, Peter Baumgarten, Patrick N. Harter, and Karl H. Plate

17. Quantitative Cerebral Blood Flow Measurements Using MRI

Eric R. Muir, Lora Talley Watts, Yash Vardhan Tiwari, Andrew Bresnen, and Timothy Q. Duong

18. Fluorescent Angiogenesis Models Using Gelfoam ® Implanted in Transgenic Mice Expressing Fluorescent Proteins

Robert M. Hoffman

19. Laser Speckle Contrast Imaging to Measure Changes in Cerebral Blood Flow

Ian R. Winship

20. Laser Doppler Flowmetry to Measure Changes in Cerebral Blood Flow

Brad A. Sutherland, Tamer Rabie, and Alastair M. Buchan

Part IV: Determining the Role of Candidate Genes in Cerebral Angiogenesis

21. Defining the Role Of HIF and Its Downstream Mediators in Hypoxic-Induced Cerebral Angiogenesis

Xiaoyan Sun, Constantinos P. Tsipis, Girriso F. Benderro, Kui Xu, and Joseph C. LaManna

22. Inducible Gene Deletion in Glial Cells to Study Angiogenesis in the Central Nervous System

Hye Shin Lee and Joseph H. McCarty

23. Bone Marrow Chimera Experiments to Determine the Contribution of Hematopoietic Stem Cells to Cerebral Angiogenesis

Marcia Regina Machein and Karl H. Plate

24. Novel Methods for Accurate Identification, Isolation, and Genomic Analysis of Symptomatic Micro-Environments in Atherosclerotic Arteries

Mark Slevin, Maribel Baldellou, Elspeth Hill, Yvonne Alexander, Garry McDowell, Christopher Murgatroyd, Michael Carroll, Hans Degens, Jerzy Krupinski, Norma Rovira, Mohammad Chowdhury, Ferdinand Serracino-Inglott, and Lina Badimon

Part V: Stimulation of Cerebral Angiogenesis by Gene Delivery

25. Induction of Brain Arteriovenous Malformation in the Adult Mouse

Wanqiu Chen, William L. Yo
Providing a selection of the key techniques that are used in characterizing cerebral angiogenesis, Cerebral Angiogenesis: Methods and Protocols aims to define the cellular and molecular mechanisms underlying this important process. Divided into six parts, this detailed volume examines cerebral angiogenesis occurring in different scenarios, a variety of different models in which cerebral angiogenesis can be studied, methods to characterize and quantify angiogenic events as well as several different approaches to measure changes in cerebral blood flow, different approaches to investigate the role of specific candidate genes in cerebral angiogenesis, methods of therapeutically manipulating cerebral angiogenesis by gene delivery, and finally important approaches to examine cerebral angiogenic mechanisms in vitro. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their specific topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.
Comprehensive and decidedly practical, Cerebral Angiogenesis: Methods and Protocols should be a vital resource for all researchers, both those new to this field as well as those looking to use more specialized and sophisticated techniques to examine blood vessel growth in the brain.

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