The Reticuloendothelial System and Atherosclerosis
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The Reticuloendothelial System and Atherosclerosis

Proceedings of an International Symposium on Atherosclerosis and the Reticuloendothelial System, Held in Como, Italy, September 8-10, 1966
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Rodolfo Paoletti
994 g
254x178x28 mm

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Methodology.- Application of a Mathematical Model to the Study of RES Phagocytosis in Mice.- The Use of Radioiodinated Latex Particles for In Vivo Studies of Phagocytosis.- Interaction of Charged Colloids with the RES.- The Potential Use of Glutaraldehyde-Fixed Liver Cells in the Study of Hepatic Reticuloendothelial and Parenchymal Cell Metabolism.- The Function of the Reticuloendothelial System Studied with Isolated Perfused Rat Livers.- Reticuloendothelial Excretion Via the Bronchial Tree.- Kinetics of the Phagocytosis of Repeated Injections of Colloidal Carbon: Blockade, A Latent Period or Stimulation? A Question of Timing and Dose.- Morphology.- Comparative Morphology of Macrophages in Tissue Culture.- Fine Structural Aspects of Reticuloendothelial Blockade.- The Cellular Basis of RE Stimulation: The Effects on Peritoneal Cells of Stimulation with Glyceryl Trioleate, Studied by EM and Autoradiography.- Cytodynamics of Rat Lung in Response to Freud's Adjuvant.- Esterase Histochemistry of Reticuloendothelial Cells.- Comparative Cytology of Alveolar and Peritoneal Macrophages from Germfree Rats.- Factors Influencing and Regulating Activity.- The Role of the Environment in Determining the Discriminatory Activity of the Human Phagocytic Cell.- Some Effects of Divalent Cations on In Vitro Phagocytosis.- The Engulfing Potential of Peritoneal Phagocytes of Conventional and Germfree Mice.- Pharmacological Stimulation and Depression of the Phagocytic Function of the RES.- The Action of Some Natural Substances on RES.- Effect of Bacillus Calmette Guerin on the Metabolism of Alveolar Macrophages.- Reticuloendothelial System Stimulation by Estrogens and Thorium Dioxide Retention in Rat Liver.- The Effects of Steroid Hormones on Local and General Reticuloendothelial Activity: Relation of Steroid Structure to Function.- Involvement in Host Defense; Endotoxin and Cardiovascular Shock, Infection, and Immune Reactions.- The Quantitative Response of the Host Defense System after Stimulation.- The Dissimilar Effects of Two RES Stimulants on Shock.- Comparative Effect of Endotoxin and Reticuloendothelial "Blocking" Colloids on Selected Inducible Liver Enzymes.- On the Nature of Some Nonspecific Host Responses in Endotoxin-Induced Resistance to Infection.- The Effect of Opsonized Colloids on the Enhancement of Endotoxin Lethality.- The Effect of a Reticuloendothelial-Depressing Substance on Survival from Shock.- Effect of Dextrans on Bacterial Infections in Mice.- Prevention and Treatment of Friend Leukemia Virus (FLV) Infection by Interferon-Inducing Synthetic Polyanions.- Immunoglobulin Synthesis in the Rat.- Modifications of Antibody Synthesis by Chloramphenicol.- Arthritis - An Example of Inflammation Based on Particles.- A Major Fault in Diabetic Inflammation: Failure of Leucocytic Glycogen Transfer to Histiocytes.- Role in Lipid Metabolism and Atherosclerosis.- Participation of Hepatic Parenchymal and Kupffer Cells in Chylomicron and Cholesterol Metabolism.- Importance of the Aging in the Relationships between the Reticuloendothelial System and Cholesterol Transport.- Arteriopathy Induced by Reticuloendothelial Blockade.- A Form of Immunological Atherosclerosis.- Synthetic Cholesterol-Ester Antigens in Experimental Atherosclerosis.- Atherosclerosis Induced Experimentally by Repeated Intravenous Administration of Hypercholesterolemic Serum and of Lipoproteins.- Experimental Arteriopathy Induced in the Rabbit Through Rat Aorta Homogenate Injections: A Study of the Aortic Tissue Specificity.- Enzymatic Activity of the Serum and the Aortic Wall in Animals Immunized by Homologous and Heterologous Aortic Extracts.- Phagocytosis of Platelets by Monocytes in Organizing Arterial Thrombi.- Platelets, Atherosclerosis, and Lipid Metabolism.- Plasma Clearance of Products of Fibrinolysis.- Author Index.
The circulatory system is usually considered to be composed of tubes of various diameters, characterized by collateral and terminal branches. There is also a tendency to treat blood vessels merely as conducting tubes in which the various structures of the wall act as mechanical pumps wlrich modify their diameter. This is, of course, not so. In fact, we know that blood vessels, and in particular arteries, are organs with personalities of their own and a particular susceptibility to several diseases. In addition, blood vessels differ in structure, according to their localization, and age at differing rates. The experimental work car ried out so far clearly confirms the data that have come from spontaneous human pathology; experimentally induced arterial lesions have a definite tendency to appear in certain arteries and not in others, depending on the experimental procedures used, and in each specific artery the lesions appear to have a specific location. We now know that the arterial wall is a metabo licallyactive structure, in which a number of enzyme activities have been clearly demonstrated. It possesses a sensitive vasa vasorum apparatus and a specific reactivity to various lesion-inducing stimuli. We must also remember that the arterial wall is in continuous contact with the blood circulating through the endothelial cells lining the vascular bed. It is obvious, therefore, that any variation in the circulating blood mass can modify the morphology as well as the function of the vessel wall.

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