Genomics, Proteomics, and the Nervous System
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Genomics, Proteomics, and the Nervous System

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James D. Clelland
1037 g
242x167x41 mm
2, Advances in Neurobiology
1. Discusses research designed to increase our understanding of the nervous system and its structures and activities
2. Includes experimental approaches such as genome-wide expression analysis and the utilization of tissue or animal models to provide data that allows for more focused investigations to test hypotheses
3. Written by accomplished leaders in this field
Part 1: DevelopmentChapter 1: The Genomics of Turner Syndrome and Sex-biased Neuropsychiatric Disorders
Phoebe M.Y. Lynn, Evangelia Stergiakouli, William Davies

Chapter 2: Mental Retardation and Human Chromosome 21 Gene Overdosage: From Functional Genomics and Molecular Mechanisms towards Prevention and Treatment of the Neuropathogenesis of Down Syndrome
Mohammed Rachidi and Carmela Lopes

Chapter 3: Epigenetic programming of stress responses and trans-generational inheritance through natural variations in maternal care
Ian C.G. Weaver

Chapter 4: Prenatal Viral Infection in Mouse: an Animal Model of Schizophrenia
S. Hossein Fatemi and Timothy D. Folsom

Chapter 5: Proteomic actions of growth hormone in the nervous system
Steve Harvey and Marie-Laure Baudet

Part 2: Learning and Memory
Chapter 6: Gene expression and signal transduction cascades mediating estrogen effects on memory
Kristina K. Aenlle and Thomas C. Foster

Chapter 7: Diagnostic genome profiling in mental retardation
David A. Koolen, Joris A. Veltman, and Bert B.A. de Vries

Chapter 8: Genomic Imprinting and Sexual Experience-Dependent Learning in the Mouse
William T. Swaney and Eric B. Keverne

Chapter 9: Proteomic Analysis of the Postsynaptic Density
Ayse Dosemeci

Part 3: Behavior
Chapter 10: Functional Genomic Dissection of Speech and Language Disorders.
Sonja C. Vernes and Simon E. Fisher.

Chapter 11: Studying Human Circadian Behavior Using Peripheral Cells
Lucia Pagani, Anne Eckert, and Steven A. Brown

Chapter 12: Genome-wide expression profiles of amygdala and hippocampus in mice after fear conditioning
Zheng Zhao and Yinghe Hu

Part 4: Psychiatric Disorders
Chapter 13: Genetic Studies of Schizophrenia
Brien Riley

Chapter 14: Proteomics of the Anterior Cingulate Cortex in Schizophrenia
Danielle Clark, Irina Dedova, Izuru Matsumoto

Chapter 15: Proteome Effects Of Antidepressant Medications
Lucia Carboni, Chiara Piubelli, and Enrico Domenici

Part 5: Neurological Disorders
Chapter 16: MicroRNAs in Neurodegenerative Disorders
Catherine L. Clelland and James D. Clelland

Chapter 17: Specific and surrogate cerebrospinal fluid markers in Creutzfeldt-Jakob disease
Gianluigi Zanusso, Michele Fiorini, Pier Giorgio Righetti, and Salvatore Monaco

Chapter 18: Genome-Wide Expression Studies In Autism-Spectrum Disorders: Moving From Neurodevelopment To Neuroimmunology
Roberto Sacco, Antonio M. Persico, Krassimira A. Garbett, and Károly Mirnics

Chapter 19: Protein expression profile of Alzheimer's disease mouse model generated by Difference Gel Electrophoresis (DIGE) approach
Daria Sizova

Chapter 20: Proteomic Analysis of CNS Injury and Recovery
Günther K.H. Zupanc and Marianne M. Zupanc

Chapter 21: Maldi Imaging Of Formalin-Fixed Paraffin-Embedded Tissues: Application To Model Animals Of Parkinson Disease For Biomarker Hunting
Isabelle Fournier , Julien Franck, Céline Mériaux, and Michel Salzet

Chapter 22: Comparative Proteomic Analysis as a method to investigate Inflammatory and Neuropathic Pain
Ellen Niederberger
This Volume of the Handbook discusses research designed to increase our understanding of the nervous system and its structures and activities, through the utilization of genomic and proteomic technologies, addressing facets including development and epigenetic regulation, functions in learning and memory, and changes associated with neurological and psychiatric disorders.

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