Hematology

Get the expert guidance you need to offer your patients the best possible outcomes with Hematology: Basic Principles and Practice, 7th Edition. This thoroughly up-to-date text contains both unparalleled scientific content and must-know clinical guidance, so you can enhance your problem-solving skills and make optimal use of the newest diagnostic techniques and therapeutic options in this fast-changing field.

• Delivers state-of-the-art information and guidance from editors and global contributors who are at the forefront of their respective subspecialty areas.
• Features sweeping content updates throughout, including basic science research which serves as a foundation for modern hematology, recent advances in stem cell transplantation, clinical advances in the treatment of each of the hematologic malignancies, immune checkpoint inhibitors, molecular diagnostics, transfusion medicine, and much more.
• Includes several new chapters including Epigenetics and Epigenomics, Stem Cell Model of Hematologic Diseases, Multiple Myeloma, IND Enabling Processes for Cell-Based Therapies, and Immune Checkpoint Blockade in Hematologic Malignancies.
• New Virtual Microscope with the ability to zoom in on high-quality digital hematopathology slides and frequent content updates accessible anywhere, any time on your favorite digital device.
• Expert Consult(TM) eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, Q&As, and references from the book on a variety of devices.

1. Anatomy and Physiology of the Gene
2. Epigenetics and Epigenomics
3. Genomic Approaches to Hematology
4. Regulation of Gene Expression, Transcription, Splicing and RNA Metabolism
5. Protein Synthesis, Processing, and Trafficking
6. Protein Architecture: Relationship of Form and Function
7. Signaling Transduction and Metabolomics
8. Pharmacogenomics and Hematologic Diseases
9. Hematopoietic Stem Cell Biology
10. Stem Cell Model of Hematologic Malignancies
11. Hematopoietic Microenvironment
12. Cell Adhesion
13. Hematopoietic Cell Trafficking and Chemokines
14. Interactions between Hematopoietic Stem and Progenitor Cells and the Bone Marrow: Current Biology of Stem Cell Homing and Mobilization
15. Vascular Growth in Health and Disease
16. Cytokine/Receptor families and signal transduction
17. Control of Cell Division
18. Cell Death
19. Overview and Compartmentalization of the Immune System
20. B-Cell Development
21. T-Cell Immunity
22. Natural Killer Cell Immunity
23. Dendritic Cell Biology
24. Complement and Immunoglobulin biology leading to clinical translation
25. Tolerance and Autoimmunity
26. Biology of Erythropoiesis, Erythroid Differentiation, and Maturation
27. Granulocytopiesis and Monocytopoiesis
28. Thrombocytopoiesis
29. Inherited Forms of Bone Marrow Failure
30. Aplastic Anemia
31. Paroxysmal Nocturnal Hemoglobinuria
32. Acquired Disorders of Unilineage Blood Cell Production
33. Pathobiology of the Human Erythrocyte and Its Hemoglobins
34. Approach to Anemia in the Adult and Child
35. Pathophysiology of Iron Homeostasis
36. Disorders of Iron Metabolism: Iron Deficiency and Overload
37. Anemia of Chronic Diseases
38. Heme Biosynthesis and Its Disorders: Porphyrias and Sideroblastic Anemias
39. Megaloblastic Anemias
40. Thalassemia Syndromes
41. Pathobiology of Sickle Cell Disease
42. Sickle Cell Disease: Clinical Features and Management
43. Hemoglobin Variants Associated with Hemolytic Anemia, Altered Oxygen Affinity, and Methemoglobinemias
44. Red Blood Cell Enzymopathies
45. Red Blood Cell Membrane Disorders
46. Autoimmune Hemolytic Anemia
47. Extrinsic Nonimmune Hemolytic Anemias
48. Granulocytosis, Granulocytopenia, Monocytosis, and Monocytopenia
49. Lymphocytosis, Lymphocytopenia, Hypergammaglobulinemia, and Hypogammaglobulinemia
50. Disorders of Phagocyte Function
51. Congenital Disorders of Lymphocyte Function
52. Histiocytic Disorders
53. Lysosomal Storage Diseases: Perspectives and Principles
54. Infectious Mononucleosis and Other Epstein-Barr Virus-Associated Diseases
55. Progress in the Classification of Hematopoietic and Lymphoid Neoplasms: Clinical Implications
56. The CytoGenomic Basis of Hematological Malignancies
57. Pharmacology and Molecular Mechanisms of Antineoplastic Agents for Hematologic Malignancies
58. Pathobiology of Acute Myeloid Leukemia
59. Clinical Manifestations and Treatment of Acute Myeloid Leukemia
60. Myelodysplastic Syndromes: Biology and Treatment
61. Allogeneic Hematopoietic Stem Cell Transplantation for Acute Myeloid Leukemia and Myelodysplastic Syndrome in Adults
62. Acute Myeloid Leukemia in Children
63. Myelodysplastic Syndrome and Myeloproliferative Syndrome in Children
64. Pathobiology of Acute Lymphoblastic Leukemia
65. Clinical Manifestations and Treatment in Children of Acute Lymphoblastic Leukemia
66. Acute Lymphocytic Leukemia in Adults
67. Chronic Myeloid Leukemia