Immunoregulatory Proteases in Systemic Lupus Erythematosus
ISBN-13:
9783639761269
Veröffentl:
2015
Einband:
Paperback
Erscheinungsdatum:
21.01.2015
Seiten:
136
Autor:
Khader Valli Rupanagudi
Gewicht:
221 g
Format:
220x150x9 mm
Sprache:
Englisch
Beschreibung:
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease leading to in ammatory tissue damage in multiple organs (e.g., lupus nephritis). Current treatments including steroids, antimalarials, and immunosuppressive drugs have significant side effects. There is an unmet medical need for new drugs with less side effects. We evaluated the role of two proteases, namely activated protein C (aPC) and cathepsin S (Cat S), in the pathogenesis of SLE in MRL-Fas(lpr) mice.