Tumorigenesis Research Advances

Tumourigenesis is the formation of tumours in the body, often caused by oncogenes. These tumours are the result of uncontrollable reproduction (cell division) due to alterations in the cell's genetic code, creating lesions in the tissue where they reside. Tumourigenesis can be divided into tumour initiation, promotion and progression. Oncogenomics often studies tumours caused by such a condition in hope of pinpointing genes -- pieces of genetic information -- that are susceptible to being changed (mutated) by external factors like ultraviolet light, toxic chemicals, and other carcinogens. The range of normal genetic alterations that a person's DNA undergoes over time is extraordinarily large, so it is hard to detect exactly what cause tumourigenesis. This book presents the latest research advances in the field.

Tumourigenesis is the formation of tumours in the body, often caused by oncogenes. These tumours are the result of uncontrollable reproduction (cell division) due to alterations in the cell's genetic code, creating lesions in the tissue where they reside. This book presents research advances in this field.

Preface; Stromal Vaccines and their Effect on the Tumorigenic Process; Mechanism of Tumorigenesis: Focus on Oxidative Stress, Electron Transfer and Antioxidants; Epigenetic Misregulation in Tumorigenesis; Nuclear Receptor Coregulators: Emerging Drug Targets for Treatment of Women Cancers; Effects of Nutritional Components on the Polyamine Metabolism in Gastrointestinal Cancers: Implications for New Therapeutic and Chemopreventive Strategies; From Normal to Malignant Phenotype: Survival and Cell Death Escaping Mechanisms; Transforming Potentiality in Breast Carcinogenesis; BCR-ABL in Hematopoietic Stem Cell Renewal and Chronic Myeloid Leukemia; Increased Smad7 Expression and its Significance to Proliferation and TGF-B mediated Cell Growth Suppression in Human Bronchial Epithelial Carcinogenesis; Tumorigenesis is a Disease of Heterochromatin Assembly and Disruption of the Epigenetic Mark; Index.