Problems of High Altitude Medicine and Biology

Hypoxia is and remains a major public health issue in many populated mountainous areas all over the world. This book is directly derived from a NATO-sponsored international meeting on problems of high altitude medicine and biology, which was held on the shores of lake Issyk-Kul, in Kyrghyzstan, in 2006. Overall, the meeting was an ideal mix of cell biology, integrative physiology and medical applications.

"This book is directly derived from a NATO-sponsored international meeting on problems of high altitude medicine and biology, which was held on the shores of lake of Issyk-Kul, in Kyrghyzstan, in June 5-6, 2006.

Introduction: 45 Years Of Mountain Medicine.- High Altitude Pulmonary Hypertension And Chronic Mountain Sickness-Reappraisal Of The Consensus On Chronic And Subacute High Altitude Diseases.- The Cellular Effects Of Hypoxia In The Pulmonary Circulation.- Angiogenesis And Chronic Hypoxic Pulmonary Hypertension.- Tetrahydrobiopterin And Pulmonary Hypertension.- Hypoxia-Induced Proliferation Of Human Pulmonary Arterial Smooth Muscle Cells (Pasmc) Is Involved In The Suppression Of Cyclin-Dependent Kinase Inhibitors, P21, P27 And P53.- Pulmonary Adaptation To High Altitude In Wild Mammals.- The Lung At High Altitude: Between Physiology And Pathology.- Sildenafil And Hypoxic Pulmonary Hypertension.- The Role Of Antioxidants In Modulation Of Acclimatization Processes.- Gene Polymorphisms And High Altitude Pulmonary Hypertension.- Genetic Factors In The Acute Response To Hypoxia In Animals Models.- Who Gets High Altitude Pulmonary Edema And Why?.- Effects Of Inhaled Nitric Oxide And Oxygen In High Altitude Pulmonary Edema.- Altered Autoregulation Of Cerebral Blood Flow In Hypoxia: Relevance To The Pathophysiology Of Acute Mountain Sickness.- Cardiac Limitation To Exercise Capacity At High Altitudes.- Pediatric High Altitude Heart Disease: A Hypoxic Pulmonary Hypertension Syndrome.- Clinical And Functional Features Of Chronic Obstructive Pulmonary Disease In The Highlanders Of Kyrgzstan.- Monitoring The Morphological And Functional Parameters Of Platelets In Patients With Thrombocytopenic Purpura During High Mountain Treatment.- Role Of Exogenous Hypoxia In Treatment Of Chronic Glomerulonephritis.- Atherogenesis Of Brain Vessels In Conditions Of Hypoxia In Kyrgyz Highlanders.- Particularities Of Neuropsychotropic Effects Of Mexidol In Various Altitude Conditions.- Influence Of High-Altitude Hypoxia On Adaptive And Non-Adaptive Structural Changes In The Vessels Of The Pulmonary Circulation.- Acute Oxygen Sensing Mechanisms.