Wnt Signaling in Development and Disease

Wnt signaling in Development and Disease: Molecular Mechanisms and Biological Functions reviews the core topics in Wnt signaling, from molecular pathway mechanisms to its role in embryogenesis, adult tissue homeostasis, and chronic disease. Written by a team of expert reviewers, the book provides clear and concise coverage of the core foundations of Wnt signaling before advancing to discussion of cutting-edge scientific research. Focused on the biological insights and current scientific questions of Wnt signaling, this book will be a comprehensive and definitive resource for a wide range of researchers and students in cell signaling, cell physiology, developmental biology, and biomedical engineering, as well as anyone interested in learning more about this important and complex protein network.
 
* A definitive source of information on Wnt signaling and its role in development and disease, written by leaders in the field.
 
* Explores the role of Wnt signaling in chronic disease such as melanoma, colorectal cancer, dementia, and psychiatric diseases
 
* Reviews the complex processes of signal integration and regulation
 
* Features broad discussion of Wnt signaling biology as well as detailed discussion of the pathway's role in diseases and potential clinical applications.

Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development.

Contributors vii
 
Preface xi
 
Part 1 Molecular Signaling Mechanisms: From Pathways to Networks 1
 
1 Wnt Signal Production, Secretion, and Diffusion 3
Madelon M. Maurice and Hendrik C. Korswagen
 
2 Wnt Signaling at the Membrane 15
Gary Davidson and Christof Niehrs
 
3 Wnt Signal Transduction in the Cytoplasm: an Introduction to the Destruction Complex 33
Tony W. Chen, Heather A. Wallace, Yashi Ahmed, and Ethan Lee
 
4 An Overview of Gene Regulation by Wnt/ß-Catenin Signaling 51
Chen U. Zhang and Ken M. Cadigan
 
5 Finding a Needle in a Genomic Haystack: Genome-Wide Approaches to Identify Wnt/TCF Transcriptional Targets 73
Chandan Bhambhani and Ken M. Cadigan
 
6 Introduction to ß-Catenin-Independent Wnt Signaling Pathways 89
Susanne Kühl and Michael Kühl
 
7 Molecular Mechanisms of Wnt Pathway Specificity 101
Alexandra Schambony, Guido J.R. Zaman, and Folkert Verkaar
 
8 Modulation of Wnt Signaling by Endocytosis of Receptor Complexes 113
Akira Kikuchi, Shinji Matsumoto, Katsumi Fumoto, and Akira Sato
 
9 New Insights from Proteomic Analysis of Wnt Signaling 125
Matthew P. Walker, Dennis Goldfarb, and Michael B. Major
 
10 New Insights about Wnt/ß-Catenin Pathway Mechanisms from Global siRNA Screens 137
Tenzin Gocha and Ramanuj DasGupta
 
11 Mathematical Models of Wnt Signaling Pathways 153
Michael Kühl, Barbara Kracher, Alexander Groß, and Hans A. Kestler
 
12 The Wnt's Tale: On the Evolution of a Signaling Pathway 161
Jenifer C. Croce and Thomas W. Holstein
 
Part 2 Selected Key Molecules in Wnt Signaling 177
 
13 Secreted Wnt Inhibitors or Modulators 179
Paola Bovolenta, Anne-Kathrin Gorny, Pilar Esteve, and Herbert Steinbeisser
 
14 Frizzleds as G Protein-Coupled Receptors 195
Gunnar Schulte
 
15 Dishevelled at the Crossroads of Pathways 207
Vítìzslav Bryja and Ondøej Bernatík
 
16 ß-Catenin: a Key Player in Both Cell Adhesion and Wnt Signaling 217
Jonathan Pettitt
 
17 Evolutionary Diversification of Vertebrate TCF/LEF Structure, Function, and Regulation 225
Stefan Hoppler and Marian L. Waterman
 
18 Insights from Structural Analysis of Protein-Protein Interactions by Wnt Pathway Components and Functional Multiprotein Complex Formation 239
Zhihong Cheng and Wenqing Xu
 
Part 3 Wnt Signaling in Embryonic Development and Adult Tissue Homeostasis 251
 
19 Wnt Signaling in Early Vertebrate Development: From Fertilization to Gastrulation 253
Eliza Zylkiewicz, Sergei Y. Sokol, and Stefan Hoppler
 
20 Wnt/ß-Catenin Signaling in Embryonic Stem Cells: Insights into Early Mammalian Development 267
Kathryn C. Davidson
 
21 Wnt Signaling in Neural Development 279
Richard I. Dorsky
 
22 Wnt Signaling in Heart Organogenesis 293
Stefan Hoppler, Silvia Mazzotta, and Michael Kühl
 
23 Wnt Signaling in Kidney Organogenesis 303
Kimmo Halt and Seppo Vainio
 
24 Wnt Signaling Regulation of Tissue Architecture (EMT and MET) and Morphogenesis: Consequences for Colorectal and Liver Cancer 315
Theodora Fifis, Bang M. Tran, Renate H.M. Schwab, Timothy M. Johanson, Nadia Warner, Nick Barker, and Elizabeth Vincan
 
25 Wnt Signaling in Adult Stem Cells: Tissue Homeostasis and Regeneration 329
Frank J.T. Staal and Riccardo Fodde
 
26 Restoring Tissue Homeostasis: Wnt Signaling in Tissue Regeneration After Acute Injury 339
Günes Özhan and Gilbert Weidinger
 
Part 4 Wnt Signaling in Chronic Disease 357
 
27 Wnt Signaling and Colorectal Cancer 359
Kevin Myant and Owen J. Sansom
 
28 Wnt Signaling in Melanoma 369
Jamie N. Anastas and Andy J. Chien
 
29 Wnt Signaling in Mood and Psychotic Disorders 379

Widely recognized as one of the most important signaling mechanisms in development and disease, Wnt signaling pathways are networks of proteins that play significant roles in embryogenesis or cancer development.