With the current trend for phasing out propellant-based aerosols, attention is now focused on the use of dry powder inhalers for drug delivery to the airways. Dry powder formulations have the twin advantages of environmental-friendliness and ease of use. This book addresses the problem of optimising dry powder drug formulations for effective delivery throughout the lungs.
Interactions between drug particulates are crucial in determining drug dispersion and deaggregation, and ultimately delivery efficiency. This book combines principles and factors in pharmaceutical powder technology, reviews some of the studies in dry powder formulation development, and proposes strategies for improving their efficiency.
1. Interparticulate Forces 2. Interparticulate Forces in Pharmaceutical Powders 3. Medicinal Aerosols 4. Particle Interactions with Air Streams 5. Particulate Interactions in Dry Powder Aerosols 6. Measurement of Cohesion, Adhesion and Dispersion of Powders 7. Physical Characterisation of Pharmaceutical Powders